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Diseases

Genetic and Rare Diseases Information Center (GARD)

Limb-body wall complex


Other Names for this Disease
  • Short umbilical cord syndrome
  • Umbilical cord, short
  • Body stalk anomaly
  • Aplasia of the cord
  • Cyllosomas
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Limb-body wall complex (LBWC) is a condition characterized by multiple, severe congenital abnormalities in a fetus. It typically results in openings in the anterior body wall (chest and belly) and defects of the limbs (arms and legs). Other features of LBWC may include facial clefts; a short or missing umbilical cord; scoliosis; neural tube defects; and abnormalities of the urogenital organs (i.e. kidney, bladder, and/or genitals). The exact cause of LBWC is unclear. Unfortunately, there is no cure for LBWC and it is considered to be incompatible with life (fatal).[1][2][3] The majority of affected pregnancies end in fetal demise.[4]
Last updated: 6/21/2016

References

  1. Courtney D Stephenson, DO; Charles J Lockwood, MD, MHCM; Andrew P MacKenzie, MD. Body stalk anomaly and cloacal exstrophy. UptoDate. November 2014; Accessed 4/2/2015.
  2. Keerthi Kocherla, Vasantha Kumari, and Prasada Rao Kocherla. Prenatal diagnosis of body stalk complex: A rare entity and review of literature. Indian J Radiol Imaging. Jan-Mar 2015; 25(1):67-70. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329692/.
  3. Panduranga Chikkannaiah, Hema Dhumale, Ranjit Kangle, and Rosini Shekar. Limb Body Wall Complex: A Rare Anomaly. J Lab Physicians. Jan-Jun 2013; 5(1):65-67. http://www-ncbi-nlm-nih-gov.ezproxy.nihlibrary.nih.gov/pmc/articles/PMC3758712/.
  4. Bhat A, Ilyas M, Dev G. Prenatal sonographic diagnosis of limb-body wall complex: case series of a rare congenital anomaly. Radiol Case Rep. March 15, 2016; 11(2):116-120.
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Basic Information

  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Limb-body wall complex. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Short umbilical cord syndrome
  • Umbilical cord, short
  • Body stalk anomaly
  • Aplasia of the cord
  • Cyllosomas
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.