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Diseases

Genetic and Rare Diseases Information Center (GARD)

Wells syndrome


Other Names for this Disease
  • Eosinophilic cellulitis
  • Bullous cellulitis with eosinophilia
  • Wells' syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Wells syndrome is a rare eosinophilic disorder that primarily affects the skin. Affected people typically develop a skin rash that is often proceeded by itching or burning skin. The rash consists of raised, red, swollen areas that may be warm to the touch. The symptoms generally come on rapidly and may last four to eight weeks. In some cases, the rash may recur (occur frequently or repeatedly) for years. The exact underlying cause of Wells syndrome is currently unknown; however, some scientists believe that it may be an autoimmune reactionOral or topical corticosteroids are commonly used to treat Wells syndrome, although antifungal drugs, antibiotics, immunosuppressants, and/or antihistamines have also been used with varying degrees of success.[1][2][3]
Last updated: 4/27/2015

References

  1. Familial eosinophilic cellulitis. National Organization for Rare Disorders (NORD). 2009; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/1003/viewAbstract. Accessed 12/14/2011.
  2. Wells syndrome. DermNet NZ. December 2013; http://dermnetnz.org/reactions/wells.html.
  3. Robert A Schwartz, MD, MPH. Wells Syndrome. Medscape Reference. May 2014; http://emedicine.medscape.com/article/1124844-overview.
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Basic Information

  • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.
  • The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Wells syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Eosinophilic cellulitis
  • Bullous cellulitis with eosinophilia
  • Wells' syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.