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Diseases

Genetic and Rare Diseases Information Center (GARD)

Neonatal progeroid syndrome


Other Names for this Disease
  • Wiedemann-Rautenstrauch syndrome
  • Progeroid syndrome neonatal
  • Wiedemann Rautenstrauch syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Neonatal progeroid syndrome is a rare genetic syndrome characterized by an aged appearance at birth. Other signs and symptoms include intrauterine growth restriction, feeding difficulties, distinctive craniofacial features, hypotonia, developmental delay and mild to severe intellectual disability. In most cases, affected infants pass away before age 7 months, but rare reports exist of survival into the teens or early 20s. Although the exact underlying cause of neonatal progeroid syndrome is unknown, it is likely a genetic condition that is inherited in an autosomal recessive manner. Treatment is symptomatic and supportive.[1][2][3]
Last updated: 4/15/2015

References

  1. Arboleda G, Morales LC, Quintero L, Arboleda H. Neonatal progeroid syndrome (Wiedemann-Rautenstrauch syndrome): report of three affected sibs. Am J Med Genet A. July 2011; 155A(7):1712-1715.
  2. Pivnick EK. Wiedemann Rautenstrauch Syndrome. NORD. 2010; http://rarediseases.org/rare-diseases/wiedemann-rautenstrauch-syndrome/.
  3. Wiedemann-Rautenstrauch syndrome. Orphanet. March 2010; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=3455.
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Basic Information

  • The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.

In Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Neonatal progeroid syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Wiedemann-Rautenstrauch syndrome
  • Progeroid syndrome neonatal
  • Wiedemann Rautenstrauch syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.