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Diseases

Genetic and Rare Diseases Information Center (GARD)

Lucey-Driscoll syndrome


Other Names for this Disease
  • Transient familial hyperbilirubinemia
  • Transient familial neonatal hyperbilirubinemia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Lucey-Driscoll syndrome, a form of transient familial hyperbilirubinemia, is a rare metabolic disorder that leads to very high levels of bilirubin in a newborn's blood. Babies with this disorder may be born with severe jaundice (yellow skin), yellow eyes and lethargy. It occurs when the body does not properly break down (metabolize) a certain form of bilirubin.  If untreated, this condition can cause seizures, neurologic problems (kernicterus) and even death. Treatment for Lucey-Driscoll syndrome includes phototherapy with blue light (to treat the high level of bilirubin in the blood) and an exchange transfusion is sometimes necessary.[1] Different inheritance patterns have been reported and in some cases, it occurs in individuals with no family history of the condition.
Last updated: 11/15/2010

References

  1. Diana Chambers, David Zieve. Transient familial hyperbilirubinemia. MedlinePlus. August 11, 2009; http://www.nlm.nih.gov/medlineplus/ency/article/001196.htm. Accessed 11/8/2010.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Lucey-Driscoll syndrome. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.

In Depth Information

  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Lucey-Driscoll syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Transient familial hyperbilirubinemia
  • Transient familial neonatal hyperbilirubinemia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.