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Diseases

Genetic and Rare Diseases Information Center (GARD)

Meningoencephalocele


Other Names for this Disease
  • Encephalomeningocele
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Cause

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What causes meningoencephalocele?

The exact cause of meningoencephalocele is not known. Some studies have suggested that environmental factors could play a role in causing the condition. Exposure during pregnancy to aflatoxins, toxins produced by a mold that grows in nuts, seeds, and legumes, has been proposed to be a possible cause in some cases. However, its potential role in causing the condition is unclear. It has also been suggested that folate deficiency during pregnancy might play a role, because the condition is so closely related to spina bifida, which can be caused by folate deficiency. However, there have been no studies regarding the relationship of maternal folate deficiency and meningoencephalocele.[1] There might additionally be some underlying genetic factors given evidence of familial clustering and cases of meningoencephalocele identified in individuals with an underlying genetic disorder.[2][3] Further studies are needed to to clarify what may cause the meningoencephalocele.
Last updated: 4/27/2016

References
  1. Sitthiporn Agthong and Viroj Wiwanitkit. Encephalomeningocele cases over 10 years in Thailand: a case series. BMC Neurology. 2002; 2:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC113760/.
  2. Meloni VA, Moysés-Oliveira M, Melo MC, Caneloi TP, Dantas AG, Soares MF, Fock R, Rodrigues de Nicola PD, Dias-da-Silva MR, Melaragno MI. Novel homozygous ALX4 mutation causing frontonasal dysplasia-2 in a patient with meningoencephalocele. ClinGen. May 11 2015; 88(6):593-6. http://www.ncbi.nlm.nih.gov/pubmed/25963140.
  3. Suphapeetiporn K1, Mahatumarat C, Rojvachiranonda N, Taecholarn C, Siriwan P, Srivuthana S, Shotelersuk V. Risk factors associated with the occurrence of frontoethmoidal encephalomeningocele. European Journal of Medical Genetics. Mar 12 2008; 12(2):102-7. http://www.ncbi.nlm.nih.gov/pubmed/17869141.


Other Names for this Disease
  • Encephalomeningocele
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.