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Diseases

Genetic and Rare Diseases Information Center (GARD)

Miller-Fisher syndrome


Other Names for this Disease
  • Cranial variant of Guillain-Barré syndrome
  • Cranial variant of GBS
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Overview

Miller-Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barré syndrome. It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. Like Guillain-Barré syndrome, symptoms may be preceded by a viral illness. Additional symptoms include generalized muscle weakness and respiratory failure. The majority of individuals with Miller-Fisher syndrome have a unique antibody that characterizes the disorder. Treatment includes intravenous immunoglobulin (IVIg) or plasmapheresis (a procedure in which antibodies are removed from the blood) and supportive care.[1]
Last updated: 10/21/2011

References

  1. NINDS Miller Fisher Syndrome Information Page. NINDS. August 2011; http://www.ninds.nih.gov/disorders/miller_fisher/miller_fisher.htm. Accessed 10/21/2011.
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Basic Information

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Miller-Fisher syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Cranial variant of Guillain-Barré syndrome
  • Cranial variant of GBS
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.