Orofaciodigital syndrome 2
- OFD syndrome 2
- Oral-facial-digital syndrome type 2
- Mohr syndrome
- Orofaciodigital syndrome II
Your QuestionI have a pregnant colleague that has been told her unborn child has Mohr syndrome (also known as orofaciodigital syndrome 2). I work in the health care field and have never heard of this disorder. I am looking for credible information that will help me understand this syndrome. I want to be informed.
We have identified the following information that we hope you find helpful. If you still have questions, please contact us.
Questions on this page
- What is orofaciodigital syndrome type 2?
- What are the signs and symptoms seen in orofaciodigital syndrome type 2?
- What treatment is available for orofaciodigital syndrome type 2?
- What prognosis is associated with orofaciodigital syndrome type 2?
- What causes orofaciodigital syndrome type 2?
- How is orofaciodigital syndrome type 2 inherited?
- How can I find a genetics professional in my area?
- How can I find additional information and supportive resources for orofaciodigital syndrome type 2?
Although the signs and symptoms that occur in people with orofaciodigital syndrome type 2 may vary, the following findings may be present:Facial findings
- Nodules (bumps) of the tongue
- Cleft lip
- Thick frenula (a strong cord of tissue that is visible and easily felt if you look in the mirror under your tongue and under your lips)
- Dystopia canthorum (an unusually wide nasal bridge resulting in widely spaced eyes)
Finger and toe findings
- Clinobrachydactyly (narrow, short fingers and toes)
- Syndactyly (fused fingers and toes)
- Polydactyly (presence of more than five fingers on hands and/or five toes on feet)
- Y-shaped central metacarpal (bone that connects the fingers to the hands)
Other possible findings
- Conductive hearing loss
- Central nervous system impairments (porencephaly and hydrocephaly)
- Heart defects (atrioventricular canal [endocardial cushion] defects)
Genetics clinics are a source of information for individuals and families regarding genetic conditions, treatment, inheritance, and genetic risks to other family members. More information about genetic consultations is available from Genetics Home Reference. To find a genetics clinic, we recommend that you contact your primary healthcare provider for a referral.
The following online resources can help you find a genetics professional in your community:
- The National Society for Genetic Counselors provides a searchable directory of US and international genetic counseling services.
- The American College of Medical Genetics has a searchable database of US genetics clinics.
- The University of Kansas Medical Center provides a list of US and international genetic centers, clinics, and departments.
- The American Society of Human Genetics maintains a database of its members, which includes individuals who live outside of the United States. Visit the link to obtain a list of the geneticists in your country, some of whom may be researchers that do not provide medical care.