Orofaciodigital syndrome 2
- OFD syndrome 2
- Oral-facial-digital syndrome type 2
- Mohr syndrome
- Orofaciodigital syndrome II
Your QuestionI have a pregnant colleague that has been told her unborn child has Mohr syndrome (also known as orofaciodigital syndrome 2). I work in the health care field and have never heard of this disorder. I am looking for credible information that will help me understand this syndrome. I want to be informed.
We have identified the following information that we hope you find helpful. If you still have questions, please contact us.
Questions on this page
- What is orofaciodigital syndrome type 2?
- What are the signs and symptoms seen in orofaciodigital syndrome type 2?
- What treatment is available for orofaciodigital syndrome type 2?
- What prognosis is associated with orofaciodigital syndrome type 2?
- What causes orofaciodigital syndrome type 2?
- How is orofaciodigital syndrome type 2 inherited?
- How can I find a genetics professional in my area?
- How can I find additional information and supportive resources for orofaciodigital syndrome type 2?
Although the signs and symptoms that occur in people with orofaciodigital syndrome type 2 may vary, the following findings may be present:Facial findings
- Nodules (bumps) of the tongue
- Cleft lip
- Thick frenula (a strong cord of tissue that is visible and easily felt if you look in the mirror under your tongue and under your lips)
- Dystopia canthorum (an unusually wide nasal bridge resulting in widely spaced eyes)
Finger and toe findings
- Clinobrachydactyly (narrow, short fingers and toes)
- Syndactyly (fused fingers and toes)
- Polydactyly (presence of more than five fingers on hands and/or five toes on feet)
- Y-shaped central metacarpal (bone that connects the fingers to the hands)
Other possible findings
- Conductive hearing loss
- Central nervous system impairments (porencephaly and hydrocephaly)
- Heart defects (atrioventricular canal [endocardial cushion] defects)
The following online resources can help you find a genetics professional in your community:
- The National Society for Genetic Counselors provides a searchable directory of US and international genetic counseling services.
- The American College of Medical Genetics has a searchable database of US genetics clinics.
- The American Society of Human Genetics maintains a database of its members, which includes individuals who live outside of the United States. Visit the link to obtain a list of the geneticists in your country, some of whom may be researchers that do not provide medical care.