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Diseases

Genetic and Rare Diseases Information Center (GARD)

Chromosome 3p- syndrome


Other Names for this Disease
  • Del(3p) syndrome
  • Chromosome 3, monosomy 3p25
  • Deletion 3p25
  • Chromosome 3pter-p25 Deletion Syndrome
  • Telomeric monosomy 3p
Related Diseases
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Inheritance

Newline Maker

Is chromosome 3p- syndrome inherited?

In most cases, chromosome 3p- syndrome occurs for the first time in the affected person (de novo mutation). However, the deletion is rarely inherited from a parent. In these cases, the deletion is passed down in an autosomal dominant manner. This means that a person with chromosome 3p- syndrome has a 50% chance with each pregnancy of passing the condition on to his or her child.

In theory, it is possible for a parent to not have the deletion in their chromosomes on a blood test, but have the deletion in some of their egg or sperm cells only. This phenomenon is called germline mosaicism. In these rare cases, it would be possible to have another child with the deletion. To our knowledge, this has not been reported with chromosome 3p- syndrome.[1]

People interested in learning more about genetic risks to themselves or family members should speak with a genetics professional.
Last updated: 5/10/2015

References
  1. 3p25 deletions. Unique. 2013; http://www.rarechromo.org/information/Chromosome%20%203/3p25%20deletions%20FTNW.pdf. Accessed 7/8/2014.


Other Names for this Disease
  • Del(3p) syndrome
  • Chromosome 3, monosomy 3p25
  • Deletion 3p25
  • Chromosome 3pter-p25 Deletion Syndrome
  • Telomeric monosomy 3p
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.