Multiple endocrine neoplasia type 2
Multiple endocrine neoplasia, type 2 (MEN2) is an inherited disorder in which one or more of the endocrine glands are overactive or form a tumor. Endocrine glands most commonly involved include:
- Adrenal (about half the time)
- Parathyroid (20% of the time)
- Thyroid (almost all of the time)
MEN2 is caused by a defect in the RET gene. This defect causes many tumors to appear in the same person, but not necessarily at the same time. The adrenal tumor is called a pheochromocytoma, and the thyroid tumor is a medullary carcinoma of the thyroid. The condition is usually inherited in an autosomal dominant pattern.
MEN2 is divided into three subtypes: type 2A, type 2B, and familial medullary thyroid carcinoma (FMTC). These subtypes differ in their characteristic signs and symptoms and risk of specific tumors. The features of this disorder are relatively consistent within any one family.
- Dugdale DC, Chen YB. Multiple endocrine neoplasia (MEN) II. MedlinePlus. 2010; http://www.nlm.nih.gov/medlineplus/ency/article/000399.htm. Accessed 3/18/2011.
- Multiple endocrine neoplasia. Genetics Home Reference (GHR). 2006; http://ghr.nlm.nih.gov/condition/multiple-endocrine-neoplasia. Accessed 8/25/2010.
Your Questions Answeredby the Genetic and Rare Diseases Information Center
Please contact us with your questions about Multiple endocrine neoplasia type 2. We will answer your question and update these pages with new resources and information.
- Genetics Home Reference (GHR) contains information on Multiple endocrine neoplasia type 2. This website is maintained by the National Library of Medicine.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Multiple endocrine neoplasia type 2. Click on the link to view a sample search on this topic.