Normokalemic periodic paralysis
Other Names for this Disease
- Periodic paralysis type 3
- Normokalemic PP
- Potassium-sensitive normokalemic periodic paralysis
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 It was initially considered a distinct condition, but most physicians now consider it to be a variant form of hyperkalemic periodic paralysis. People with hyperkalemic periodic paralysis have increased potassium levels during an attack; people with the normokalemic form do not experience any change in their potassium levels during weakness, but most grow weak when given potassium. Studies have shown that both forms of the condition are caused by mutations in the SCN4A gene and it is inherited in an autosomal dominant manner. The goals of treatment are to relieve acute symptoms and prevent further attacks.Normokalemic periodic paralysis (NormoKPP) is an inherited muscle disorder characterized by episodic attacks of muscle weakness.
Last updated: 9/12/2012
- Young-Wha Song et al. Normokalemic periodic paralysis is not a distinct disease. Muscle and Nerve. August 2012; epub:
- S. Vicart et al. New mutations of SCN4A cause a potassium-sensitive normokalemic periodic paralysis. Neurology. December 2004; 63(11):2120-2127.
- What is periodic paralysis?. Periodic Paralysis International. June 21, 2011; http://hkpp.org/. Accessed 9/11/2012.
- The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Normokalemic periodic paralysis. Click on the link to view a sample search on this topic.