See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.
 It is mainly characterized by swelling of the lip with hyperplasia of the salivary glands; secretion of a clear, thick mucus; and variable inflammation. Enlargement and chronic exposure of the mucous membrane on the lower lip becomes affected by the environment, leading to erosion, ulceration, crusting, and, occasionally, infection. Cheilitis glandularis is more common in adult males, although cases have been described in women and children. In Caucasians, it is associated with a relatively high incidence of squamous cell carcinoma of the lip. Although there may be a genetic susceptibility, no definitive cause has been established. Treatment may include surgical excision by vermilionectomy (sometimes called a lip shave), but treatment varies for each individual.Cheilitis glandularis is a rare inflammatory disorder of the lip.
Last updated: 9/30/2015
- Ellen Eisenberg. Cheilitis Glandularis. Medscape Reference. March 6, 2014; http://emedicine.medscape.com/article/1078725-overview. Accessed 9/30/2015.
- Lourenco S, Nico M. Cheilitis glandularis. Orphanet. January 2015; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=1221. Accessed 9/30/2015.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Cheilitis glandularis. Click on the link to view a sample search on this topic.
- Kids Skin Health, a American Academy of Dermatology's web site, provides kids, teens, and parents with information on skin conditions. Click on Kids Skin Health to access this Web site.