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Diseases

Genetic and Rare Diseases Information Center (GARD)

Pili annulati


Other Names for this Disease
  • Ringed hair
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Overview

Pili annulati is a hair disorder. In pili annulati, affected hair has a pattern of light and dark banding.[1] People with pili annulati may describe their hair as "striped" or as having silvery beads. Pili annulati typically involves 20-80% of scalp hair, however it can involve facial and body hair as well. Affected hairs may be more prone to breakage.  Pili annulati can present in infancy, childhood, or later in life.[2][3][4] It can be seen with the naked eye, however it may be more difficult to see in people with dark hair.[4] Diagnosis is confirmed by polariscopic and/or electron microscopic examination of affected hairs.[2][3][4] The condition runs in an autosomal dominant fashion in some families. Reduced penetrance and variable expression has been described. Sporadic cases have also been reported.[4]
Last updated: 11/5/2015

References

  1. Vedamurthy M et al.,. Pili Annulati: A Case Report in Young Siblings. J Clin Exp Dermatol Res. 2013; 4:186. Accessed 11/5/2015.
  2. Werner K et al.,. Pili annulati associated with hair fragility: cause or coincidence?. Cutis. 2013 Jan; 91(1):36-8. Accessed 11/5/2015.
  3. Akoglu G et al.,. Pili annulati with fragility: Electron microscopic findings of a case. Int J Trichology. 2012 Apr; 4(2):89-92. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500080/. Accessed 11/5/2015.
  4. Laniosz V et al.,. Pili annulati masquerading as hypotrichosis. Pediatr Dermatol. 2013 Jul-Aug; 30(4):510-1. Accessed 11/5/2015.
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In Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Pili annulati. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Ringed hair
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.