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Diseases

Genetic and Rare Diseases Information Center (GARD)

Type 1 plasminogen deficiency


Other Names for this Disease
  • Hypoplasminogenemia
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Treatment

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How might type 1 plasminogen deficiency be treated?

The treatment options available for type 1 plasminogen deficiency are few. However, some cases of ligneous conjunctivitis, the most common disease manifestation, have been successfully treated using a combination of surgery and plasminogen administration. Surgery alone to remove the eye growths can be a temporary fix; however, irritation secondary to surgery can result in recurrence. Other therapies that have been utilized with a varying degree of success include: corticosteroids, immunosuppressants (Cyclosporine), blood thinners (heparin), alpha-chymotrypsin (digestive enzyme), plasma infusion (white blood cells), and anti-virals.[1][2]
Last updated: 6/16/2016

References
  1. Colman RW, Marder VJ, Clowes AW, George JN, Goldhaber SZ. Hemostasis and Thrombosis. Philadelphia: Lippincott Williams & Wilkins; 2005;
  2. Michael J. Ang, Konstantinos I. Papageorgiou, Shu-Hong Chang, Jocelyn Kohn, Helen Chokron Garneau, Robert A. Goldberg. Topical Plasminogen as Adjunctive Treatment in Recurrent Ligneous Conjunctivitis. Ophthal Plast Reconstr Surg. April 8, 2016; http://www.ncbi.nlm.nih.gov/pubmed/27065432.


Other Names for this Disease
  • Hypoplasminogenemia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.