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Diseases

Genetic and Rare Diseases Information Center (GARD)

Type 1 plasminogen deficiency


Other Names for this Disease
  • Hypoplasminogenemia
  • Plasminogen deficiency type 1
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Treatment

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How might type 1 plasminogen deficiency be treated?

The treatment options available for type 1 plasminogen deficiency are few. However, some researchers have shown that the ligneous lesions can be reversed by plasminogen infusion, with changes occurring within 3 days and restored to normal after 2 weeks of treatment. Recurrence has been prevented by daily injections with plasminogen sufficient to achieve plasma concentrations to approximately 40% of the normal amount of plasminogen. Treatment with topical plasminogen has also been successful and resulted in dramatic improvement and complete resolution of the membranes. In some women, treatment with oral contraceptives have resulted in an increase in the levels of plasminogen and some resolution of the pseudomembrane.[1]
Last updated: 12/8/2008

References
  1. Colman RW, Marder VJ, Clowes AW, George JN, Goldhaber SZ. Hemostasis and Thrombosis. Philadelphia: Lippincott Williams & Wilkins; 2005;


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Other Names for this Disease
  • Hypoplasminogenemia
  • Plasminogen deficiency type 1
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.