Other Names for this Disease
- Poikiloderma, hereditary acrokeratotic
- Bullous acrokeratotic poikiloderma of kindler and weary
- Poikiloderma, congenital, with bullae, weary type
- Congenital bullous poikiloderma
- Poikiloderma of Kindler
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Your QuestionMy mother had Kindler Syndrome. I now have two daughters of my own. It never even crossed my mind during my pregnancies that I might be passing along this gene or give birth to a child with Kindler Syndrome. In general, what is the likelihood of me having a child with this disease?
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Kindler syndrome is inherited in an autosomal recessive pattern. This means that both parents must be a carrier of a mutation in the FERMT1 gene for there to be a chance that their child could have Kindler syndrome. Because Kindler syndrome is so rare, it is very unlikely that both members of a couple are carriers. However, if both parents are carriers, there is a 25% chance of the child being affected with Kindler syndrome, a 50% chance of the child being a carrier, and a 25% chance of the child being unaffected and not a carrier.
Last updated: 9/23/2013
- Freiman A. Kindler syndrome. eMedicine Journal. June 18, 2010; http://emedicine.medscape.com/article/1118967-overview. Accessed 11/11/2011.