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Diseases

Genetic and Rare Diseases Information Center (GARD)

Catecholaminergic polymorphic ventricular tachycardia


Other Names for this Disease
  • Bidirectional tachycardia
  • Bidirectional tachycardia induced by catecholamine
  • Catecholamine-induced polymorphic ventricular tachycardia
  • CPVT
  • CVPT
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic disorder that causes an abnormally fast and irregular heart rhythm in response to physical activity or emotional stress. Signs and symptoms include light-headedness, dizziness, and fainting. Symptoms most often develop between 7 to 9 years of age.  If untreated CPVT can cause a heart attack and death. CPVT is caused by mutations in the RYR2 or CASQ2 genes. When a RYR2 gene mutation is involved, the condition is passed through families in an autosomal dominant fashion. When CASQ2 gene mutations are involved, the condition is inherited in an autosomal recessive fashion.[1] In some cases the underlying cause can not be determined. Beta blockers are used to treat CPVT.  An Implantable Cardioverter Defibrillator (ICD) may also be needed. 
Last updated: 1/25/2013

References

  1. Catecholaminergic polymorphic ventricular tachycardia. Genetics Home Reference. December 2009; http://ghr.nlm.nih.gov/condition/catecholaminergic-polymorphic-ventricular-tachycardia. Accessed 1/25/2013.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Catecholaminergic polymorphic ventricular tachycardia. This website is maintained by the National Library of Medicine.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • MeSH® (Medical Subject Headings) is a terminology tool used by the National Library of Medicine. Click on the link to view information on this topic.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Catecholaminergic polymorphic ventricular tachycardia. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Bidirectional tachycardia
  • Bidirectional tachycardia induced by catecholamine
  • Catecholamine-induced polymorphic ventricular tachycardia
  • CPVT
  • CVPT
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.