Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Cronkhite-Canada disease


Other Names for this Disease
  • Cronkhite-Canada syndrome
  • Gastrointestinal polyposis - ectodermal changes
  • Gastrointestinal polyposis - skin pigmentation - alopecia - fingernail changes
  • Polyposis skin pigmentation alopecia fingernail changes
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Cronkhite-Canada syndrome is a rare gastrointestinal disorder characterized by widespread colon polyps, unhealthy looking (dystrophic) nails, hair loss (alopecia), darkening skin (such as on the hands, arms, neck and face), diarrhea, weight loss, stomach pain, and/or excess fluid accumulation in arms and legs (peripheral edema). The cause of the condition is not known. Treatment aims to control symptoms and provide adequate nutrition.[1][2][3]
Last updated: 5/31/2015

References

  1. Kao KT, Patel JK, Pampati V. Gastroenterol Res Pract. Epub 2009 Aug 25; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732131/?tool=pubmed. Accessed 5/31/2015.
  2. Serwin AB. Cronkhite-Canada syndrome. eMedicine. October 23, 2014; http://emedicine.medscape.com/article/1096789-overview. Accessed 5/31/2015.
  3. Cronkhite-Canada Syndrome. National Organization for Rare Disorders (NORD). 2005; http://rarediseases.org/rare-diseases/cronkhite-canada-syndrome/. Accessed 5/31/2015.
GARD Video Tutorials
GARD Video Tutorials
Learn how to find information on treatment, research, specialists, and more.
Contact GARD
Contact GARD
Contact a GARD Information Specialist with your questions about this condition.

Basic Information

  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Cronkhite-Canada disease. Click on the link to view a sample search on this topic.

Selected Full-Text Journal Articles

Other Names for this Disease
  • Cronkhite-Canada syndrome
  • Gastrointestinal polyposis - ectodermal changes
  • Gastrointestinal polyposis - skin pigmentation - alopecia - fingernail changes
  • Polyposis skin pigmentation alopecia fingernail changes
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.