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Diseases

Genetic and Rare Diseases Information Center (GARD)

Testotoxicosis


Other Names for this Disease
  • Precocious puberty, male limited
  • Sexual precocity, familial, gonadotropin-independent
  • Pubertas Praecox
  • Familial Testotoxicosis (subtype)
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

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How might testotoxicosis be treated?

Decisions regarding treatment for patients with testotoxicosis are complex.[1] Treatment typically consists of reducing hyperandrogenism in children (sexual maturation, stature) with ketoconazole or a combination of antiandrogens and aromatase inhibitors.[1][2] Recently, the use of combination therapy with bicalutamide (a potent antiandrogen agent) and anastrozole or letrozole (third-generation aromatase inhibitors) was reported to yield encouraging short-term results, including slower growth rate.[3][4] 
Last updated: 2/29/2012

References
  1. Ferry RJ, Fenton CL, Poth MPM. Precocious Pseudopuberty. eMedicine. 2009; http://emedicine.medscape.com/article/923876-overview. Accessed 2/29/2012.
  2. Carel JC. Testotoxicosis. Orphanet. 2005; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=3000. Accessed 2/29/2012.
  3. Lenz AM, Shulman D, Eugster EA, Rahhal S, Fuqua JS, Pescovitz OH, Lewis KA. Bicalutamide and third-generation aromatase inhibitors in testotoxicosis. Pediatrics. 2010; http://www.ncbi.nlm.nih.gov/pubmed/20713483. Accessed 2/29/2012.
  4. Reiter EO, Mauras N, McCormick K, Kulshreshtha B, Amrhein J, De Luca F, O'Brien S, Armstrong J, Melezinkova H. Bicalutamide plus anastrozole for the treatment of gonadotropin-independent precocious puberty in boys with testotoxicosis: a phase II, open-label pilot study (BATT). J Pediatr Endocrinol Metab. 2010; http://www.ncbi.nlm.nih.gov/pubmed/21158211. Accessed 2/29/2012.


Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Testotoxicosis. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • Precocious puberty, male limited
  • Sexual precocity, familial, gonadotropin-independent
  • Pubertas Praecox
  • Familial Testotoxicosis (subtype)
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.