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Diseases

Genetic and Rare Diseases Information Center (GARD)

Familial prostate cancer


Other Names for this Disease
  • Hereditary prostate cancer
  • Prostate cancer, familial
  • Prostate cancer, hereditary
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Overview

Familial prostate cancer is a cluster of prostate cancer within a family. Most cases of prostate cancer occur sporadically in people with no family history of the condition. However, approximately 5% to 10% of prostate cancer cases are believed to be primarily caused by a genetic predisposition to the condition.[1] In many families, the underlying genetic cause is unknown; however, some of these cases are caused by changes (mutations) in the BRCA1, BRCA2, HOXB13, or several other genes. Other cases are likely due to a combination of gene(s) and other shared factors such as environment and lifestyle.[2] High-risk cancer screening at an earlier age is typically recommended in men who have an increased risk for prostate cancer based on personal and/or family histories.
Last updated: 12/7/2015

References

  1. Genetics of Prostate Cancer–for health professionals (PDQ®). National Cancer Institute. November 2015; http://www.cancer.gov/types/prostate/hp/prostate-genetics-pdq.
  2. Prostate Cancer. Genetics Home Reference. April 2015; http://ghr.nlm.nih.gov/condition/prostate-cancer.
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Basic Information

  • You can obtain information on this topic from the Centers for Disease Control and Prevention (CDC). The CDC is recognized as the lead federal agency for developing and applying disease prevention and control, environmental health, and health promotion and education activities designed to improve the health of the people of the United States.
  • Genetics Home Reference (GHR) contains information on Familial prostate cancer. This website is maintained by the National Library of Medicine.
  • The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.
  • The National Human Genome Research Institute's (NHGRI) website has an information page on this topic. NHGRI is part of the National Institutes of Health and supports research on the structure and function of the human genome and its role in health and disease.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Familial prostate cancer. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Hereditary prostate cancer
  • Prostate cancer, familial
  • Prostate cancer, hereditary
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.