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Diseases

Genetic and Rare Diseases Information Center (GARD)

Protein C deficiency

*

* Not a rare disease

Other Names for this Disease
  • Hereditary thrombophilia due to congenital protein C deficiency
  • Hereditary thrombophilia due to PC deficiency
  • Hereditary thrombophilia due to protein C deficiency
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Cause

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What causes protein C deficiency?

Protein C deficiency can be inherited or acquired later in life. Inherited protein C deficiency is caused by mutations in the gene that provides instructions for making protein C, called the PROC gene. These mutations disrupt the protein's ability to control blood clotting. If protein C cannot control blood clotting, abnormal blood clots may form.[1]

Acquired protein C deficiency may be caused by large blood clots, liver disease, disseminated intravascular coagulation (DIC), infection (sepsis), and vitamin K deficiency. Treatment with warfarin or certain types of chemotherapy can also cause acquired protein C deficiency.[2]
Last updated: 8/6/2015

References
  1. Protein C deficiency. Genetics Home Reference. May, 2013; http://ghr.nlm.nih.gov/condition/protein-c-deficiency.
  2. Cuker A, Pollak ES. Protein C Deficiency. eMedicine Journal. August 2011; http://emedicine.medscape.com/article/205470-overview#showall. Accessed 9/20/2011.


Other Names for this Disease
  • Hereditary thrombophilia due to congenital protein C deficiency
  • Hereditary thrombophilia due to PC deficiency
  • Hereditary thrombophilia due to protein C deficiency
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.