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Diseases

Genetic and Rare Diseases Information Center (GARD)

Thrombotic thrombocytopenic purpura, acquired


Other Names for this Disease
  • Purpura, thrombotic thrombocytopenic
  • TTP
  • Moschowitz syndrome
  • Idiopathic thrombotic thrombocytopenic purpura
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Thrombotic thrombocytopenic purpura (TTP), acquired is a blood disorder characterized by low platelets (i.e., thrombocytopenia), small areas of bleeding under the skin (i.e., purpura), low red blood cell count, and hemolytic anemia. TTP causes blood clots (thrombi) to form in small blood vessels throughout the body. These clots can cause serious medical problems if they block vessels and restrict blood flow to organs such as the brain, kidneys, and heart. Resulting complications can include neurological problems (such as personality changes, headaches, confusion, and slurred speech), fever, abnormal kidney function, abdominal pain, and heart problems. Hemolytic anemia can lead to paleness, yellowing of the eyes and skin (jaundice), fatigue, shortness of breath, and a rapid heart rate. TTP, acquired usually appears in late childhood or adulthood. Affected individuals may have a single episode of signs and symptoms, or they may recur over time. This condition results from a reduction in ADAMTS13 enzyme activity caused by autoantibodies.[1]
Last updated: 4/7/2011

References

  1. Thrombotic thrombocytopenic purpura. Genetics Home Reference. 2008; http://ghr.nlm.nih.gov/condition/thrombotic-thrombocytopenic-purpura. Accessed 4/7/2011.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Thrombotic thrombocytopenic purpura, acquired. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Heart, Lung, and Blood Institute (NHLBI) has information on this topic. NHLBI is part of the National Institutes of Health and supports research, training, and education for the prevention and treatment of heart, lung, and blood diseases.
  • The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Thrombotic thrombocytopenic purpura, acquired. Click on the link to view a sample search on this topic.

Selected Full-Text Journal Articles

Other Names for this Disease
  • Purpura, thrombotic thrombocytopenic
  • TTP
  • Moschowitz syndrome
  • Idiopathic thrombotic thrombocytopenic purpura
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.