Other Names for this Disease
- X-linked juvenile retinoschisis
- X-linked retinoschisis
- Retinoschisis X-linked
- Retinoschisis juvenile X chromosome-linked
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retinal detachment) or leakage of blood vessels in the retina (vitreous hemorrhage). These can lead to blindness. Juvenile retinoschisis is caused by mutations in the RS1 gene. It is inherited in an X-linked recessive pattern. Low-vision aids can be helpful. Surgery may be needed for some complications.Juvenile retinoschisis is an eye condition characterized by impaired vision that begins in childhood and occurs almost exclusively in males. The condition affects the retina, which is a specialized light-sensitive tissue that lines the back of the eye. This affects the sharpness of vision. Central vision is more commonly affected. Vision often deteriorates early in life, but then usually becomes stable until late adulthood. A second decline in vision typically occurs in a man's fifties or sixties. Sometimes severe complications occur, including separation of the retinal layers (
Last updated: 2/27/2016
- Sieving PA, MacDonald IM, Chan S. X-Linked Juvenile Retinoschisis. GeneReviews. August 28, 2014; http://www.ncbi.nlm.nih.gov/books/NBK1222/.
- X-linked juvenile retinoschisis. Genetics Home Reference. March 2015; http://ghr.nlm.nih.gov/condition/x-linked-juvenile-retinoschisis.
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- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
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