Other Names for this Disease
- Shapiro's syndrome
- Recurrent spontaneous hypothermia with hypoplasia of the corpus callosum
- Spontaneous periodic hypothermia syndrome
- Spontaneous recurrent hypothermia syndrome
- Spontaneous periodic hypothermia
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Evaluating effective treatment options for Shapiro syndrome can be difficult because of the limited number of diagnosed cases, the periodic nature of the disease, and other factors. Nonetheless, the following have been attempted and have resulted in varying levels of success: oxcarbazepine, carbamazepine, clonidine, cyproheptadine, glycopyrrolate, bromocriptine, chlorpromazine, beta blockers, or sympathectomy. It is recommended that treatment options be discussed with a health care professional. Only a patient's personal health care provider can determine the appropriate course of treatment.
Last updated: 6/6/2016
- Duman O. Spontaneous periodic hypothermia. Orphanet. December 2013; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=29822.
- Dundar NL, Boz A, Duman O, Aydin F, Haspolat S. Spontaneous Periodic Hypothermia and Hyperhidrosis. Pediatr Neurol. 2008 Dec; 39(6):438-40. https://www.ncbi.nlm.nih.gov/pubmed/19027594.