Infantile-onset ascending hereditary spastic paralysis
Other Names for this Disease
- Spastic paralysis, infantile onset ascending
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motor neuron disease characterized by progressive weakness and stiffness of muscles in the arms, legs, and face. Initial symptoms usually occur within the first 2 years of life and include weakness of the legs, leg muscles that are abnormally tight and stiff, and eventual paralysis of the legs. Over time, muscle weakness and stiffness travels up (ascends) the body from the legs to the head. Infantile-onset ascending hereditary spastic paralysisis caused by mutations in the ALS2 gene, and this condition is inherited in an autosomal recessive pattern.Infantile-onset ascending hereditary spastic paralysis is a
Last updated: 9/1/2009
- Infantile-onset ascending hereditary spastic paralysis. Genetics Home Reference Website. May 2007; http://ghr.nlm.nih.gov/condition=infantileonsetascendinghereditaryspasticparalysis. Accessed 9/1/2009.
- Genetics Home Reference (GHR) contains information on Infantile-onset ascending hereditary spastic paralysis. This website is maintained by the National Library of Medicine.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Infantile-onset ascending hereditary spastic paralysis. Click on the link to view a sample search on this topic.