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Diseases

Genetic and Rare Diseases Information Center (GARD)

Spastic paraplegia 11


Other Names for this Disease
  • SPG11
  • Hereditary spastic paraplegia mental impairment and thin corpus callosum
  • Autosomal recessive spastic paraplegia type 11
  • Hereditary spastic paraplegia 11
  • Nakamura Osame syndrome
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Treatment

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How might spastic paraplegia 11 (SPG11) be treated?

Care for SPG11 is usually managed by a team including a primary care physicianneurologist, genetics professional (geneticist and/or genetic counselor), physical therapistsocial worker, and psychologist. Treatment is focused on alleviating symptoms and may include:
  • Medications for leg spasticity (antispastic drugs)
  • Medications to assist in bladder control (anticholinergic antispasmodic drugs) 
  • Regular physician therapy
  • Botulinum toxin and intrathecal baclofen for severe spasticity 
Regular outpatient clinic evaluations are recommended to adjust medications and physical therapy/rehabilitation routines. Routine brain MRI  and electrophysiological investigations (muscle and nerve studies) may be useful to follow the progression of the disease.[1]
Last updated: 5/31/2016

References
  1. Stevanin G, Durr A, Brice A. Spastic paraplegia 11. GeneReviews. January 31, 2013; https://www.ncbi.nlm.nih.gov/books/NBK1210/.


Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions.
Other Names for this Disease
  • SPG11
  • Hereditary spastic paraplegia mental impairment and thin corpus callosum
  • Autosomal recessive spastic paraplegia type 11
  • Hereditary spastic paraplegia 11
  • Nakamura Osame syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.