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Diseases

Genetic and Rare Diseases Information Center (GARD)

Spastic paraplegia 4


Other Names for this Disease
  • SPG4
  • Autosomal dominant spastic paraplegia 4
  • Familial spastic paraplegia autosomal dominant 2
  • FSP2
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

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How might spastic paraplegia 4 (SPG4) be treated?

Care for SPG4 is usually managed by a team including a primary care physicianneurologist, genetics professional (geneticist and/or genetic counselor), physical therapistsocial worker, and psychologist. Treatment is focused on alleviating symptoms and may include:[1]
  • Medications for leg spasticity (antispastic drugs)
  • Medications to assist in bladder control (anticholinergic antispasmodic drugs) 
  • Regular physician therapy
  • Botulinum toxin and intrathecal baclofen for severe spasticity 
Last updated: 5/27/2016

References
  1. Dürr A, Tallaksen C, Depienne C. Spastic Paraplegia 4. GeneReveiws. Aug 16 2012; https://www.ncbi.nlm.nih.gov/books/NBK1160.


Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions.
Other Names for this Disease
  • SPG4
  • Autosomal dominant spastic paraplegia 4
  • Familial spastic paraplegia autosomal dominant 2
  • FSP2
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.