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Diseases

Genetic and Rare Diseases Information Center (GARD)

Familial stomach cancer


Other Names for this Disease
  • Stomach carcinoma, familial
  • Familial stomach carcinoma
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Overview

Familial stomach cancer is a cluster of stomach cancer within a family. Most cases of stomach cancer occur sporadically in people with little to no family history of the condition; however, approximately 10% of stomach cancer is considered "familial." Although the underlying cause of some familial cases is unknown, genetic changes (mutations) are identified in a subset of people affected by gastric cancer. Hereditary cancer syndromes associated with a predisposition to gastric cancer include hereditary diffuse gastric cancer, Lynch syndrome, Li-Fraumeni syndrome, familial adenomatous polyposis, and Peutz-Jeghers syndrome. In other families, the cluster of stomach cancers may be due to a combination of gene(s) and/or other shared factors such as environment and lifestyle. Depending on the estimated risk, high-risk cancer screening and/or prophylactic surgeries are typically recommended in people who have an increased risk for stomach cancer based on their personal and/or family histories.[1][2]
Last updated: 12/16/2015

References

  1. Cabebe EC. Gastric Cancer. Medscape Reference. November, 2015; http://emedicine.medscape.com/article/278744-overview.
  2. Colvin H, Yamamoto K, Wada N, Mori M. Hereditary Gastric Cancer Syndromes. Surg Oncol Clin N Am. October 2015; 24(4):765-777.
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Basic Information

  • The American Cancer Society provides information on Familial stomach cancer. Please click on the link to access this resource.
  • Mayo Clinic has an information page on Familial stomach cancer.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Familial stomach cancer. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Stomach carcinoma, familial
  • Familial stomach carcinoma
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.