Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Familial stomach cancer


Other Names for this Disease
  • Stomach carcinoma, familial
  • Familial stomach carcinoma
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Familial stomach cancer refers to stomach cancer that occurs in multiple people within a family. Most cases of stomach cancer occur sporadically in people with little to no family history of the condition; however, approximately 10% of stomach cancer is considered "familial." Although the underlying cause of some familial cases is unknown, genetic changes (mutations) are identified in a subset of affected people. Hereditary cancer syndromes associated with a predisposition to stomach cancer include hereditary diffuse gastric cancer, Lynch syndrome, Li-Fraumeni syndrome, familial adenomatous polyposis, and Peutz-Jeghers syndrome. In other families, the cluster of stomach cancers may be due to a combination of gene(s) and/or other shared factors such as environment and lifestyle. Depending on the estimated risk, high-risk cancer screening and/or prophylactic surgeries may be recommended for people who have an increased risk for stomach cancer based on their personal and/or family histories.[1][2]
Last updated: 12/16/2015

References

  1. Cabebe EC. Gastric Cancer. Medscape Reference. November, 2015; http://emedicine.medscape.com/article/278744-overview.
  2. Colvin H, Yamamoto K, Wada N, Mori M. Hereditary Gastric Cancer Syndromes. Surg Oncol Clin N Am. October 2015; 24(4):765-777.
GARD Video Tutorials
GARD Video Tutorials
Learn how to find information on treatment, research, specialists, and more.
Your Questions Answered
Your Questions Answered
View questions about this condition answered by GARD Information Specialists. You can also submit a new question.

Basic Information

  • The American Cancer Society provides information on Familial stomach cancer. Please click on the link to access this resource.
  • Mayo Clinic has an information page on Familial stomach cancer.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Familial stomach cancer. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Stomach carcinoma, familial
  • Familial stomach carcinoma
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.