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Genetic and Rare Diseases Information Center (GARD)

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Platelet storage pool deficiency


Other Names for this Disease
  • Platelet storage pool diseases
  • Storage pool platelet disease
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Overview

Platelet storage pool deficiency refers to a group of conditions that are caused by problems with the platelet granules. Platelet granules are tiny storage sacs found within the platelets which release various substances to help stop bleeding. Platelet storage pool deficiencies occur when platelet granules are absent, reduced in number, or unable to empty their contents into the bloodstream. The signs and symptoms include frequent nosebleeds; abnormally heavy or prolonged menstruation; easy bruising; recurrent anemia; and abnormal bleeding after surgery, dental work or childbirth.[1] Platelet storage pool deficiencies may be genetic or acquired (non-genetic). They can also be part of an inherited genetic syndrome such as Hermansky-Pudlak syndrome, Chediak-Higashi syndrome, thrombocytopenia-absent radius (TAR) syndrome, and Wiskott-Aldrich syndrome. Treatment is symptomatic.[2][1][3]
Last updated: 4/14/2015

References

  1. Jewell, M., MaGann, EF, Barr, A., and Baker, R. Management of platelet storage pool deficiency during pregnancy. Australian and New Zealand Journal of Obstetrics and Gynecology. 2003; 43(2):171-172.
  2. Storage Pool Platelet Disease. Online Mendelian Inheritance of Man. March 3, 2009; http://omim.org/entry/185050. Accessed 7/30/2014.
  3. Riley RS. Platelet Storage Pool Diseases. Virginia Commonwealth University. http://www.pathology.vcu.edu/clinical/coag/SPD.pdf. Accessed 7/30/2014.
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Basic Information

  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.

In Depth Information

  • MeSH® (Medical Subject Headings) is a terminology tool used by the National Library of Medicine. Click on the link to view information on this topic.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Platelet storage pool deficiency. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Platelet storage pool diseases
  • Storage pool platelet disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.