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Diseases

Genetic and Rare Diseases Information Center (GARD)

Idiopathic thrombocytopenic purpura


Other Names for this Disease
  • ITP
  • Autoimmune thrombocytopenic purpura
  • Thrombocytopenic purpura autoimmune
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

I was first diagnosed with idiopathic thrombocytopenic purpura, which then progressed to Evans syndrome. I had a splenectomy and have since been in remission. My husband and I have been together for 10 years, and in this time I have not conceived. Can Evans syndrome cause infertility? If I do get pregnant, would there be a chance my child could have the same condition?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Can Evans syndrome cause infertility?

A review of available literature does not yield any information or case reports regarding Evans syndrome and infertility. Furthermore, infertility is not mentioned as being a sign or symptom of Evans syndrome in various resources.

Evans syndrome appears to be rare in pregnancy with only a few published cases. Because some of the medications used to treat Evan's syndrome may be harmful to a developing baby, treatment options in pregnancy can be limited. However, women with Evans syndrome can have successful pregnancies.[1]
Last updated: 11/16/2014

Can idiopathic thrombocytopenic purpura be inherited?

The cause of idiopathic thrombocytopenic purpura (ITP) is unknown. It is not thought to be genetic because it is rare for multiple people in the same family to develop this disease.[2] Only a few cases of familial ITP have been documented, including an affected woman and 3 of her 4 children, identical twins with chronic ITP, and a mother with chronic ITP who had a child with purpura. The child's purpura resolved on its own within 3 weeks while the mother remained thrombocytopenic.[3]
Last updated: 1/22/2013

Is Evans syndrome inherited?

While Evans syndrome is not thought to be inherited in most cases and rarely occurs in more than one person in a family, there are a few cases in the medical literature describing "familial Evans syndrome." The majority of familial cases involve siblings that are found to have Evans syndrome. Some of these cases were additionally associated with other symptoms, such as heart defects as well as other disorders that are known to be inherited, such as hereditary spastic paraplegia.[4][5][6]

If there is a family history of Evans syndrome, we would recommend consulting with a genetics professional to discuss risks for family members. 
Last updated: 7/28/2016

How can I find a medical professional who specializes in genetics?

To find a medical professional who specializes in genetics, you can ask your doctor for a referral or you can search for one yourself. Online directories are provided by GeneTests, the American College of Medical Genetics, and the National Society of Genetic Counselors. If you need additional help, contact a GARD Information Specialist. You can also learn more about genetic consultations from Genetics Home Reference.
Last updated: 7/28/2016

References
Other Names for this Disease
  • ITP
  • Autoimmune thrombocytopenic purpura
  • Thrombocytopenic purpura autoimmune
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.