Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Hereditary neuropathy with liability to pressure palsy


Other Names for this Disease
  • Current pressure-sensitive neuropathy
  • Hereditary neuropathy with liability to pressure palsies
  • Heterozygous microdeletion 17p11.2p12
  • HNPP
  • Polyneuropathy, familial recurrent
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Hereditary neuropathy with liability to pressure palsy (HNPP) is a disorder that affects peripheral nerves. This condition causes recurrent episodes of numbness, tingling, and/or loss of muscle function (palsy). An episode can last from several minutes to several months, but recovery is usually complete. Repeated incidents, however, can cause permanent muscle weakness or loss of sensation. The most common problem sites involve nerves in wrists, elbows, and knees. Symptoms usually begin during adolescence or early adulthood but may develop anytime from childhood to late adulthood. Symptoms vary in severity; many people never realize they have the disorder, while some people experience prolonged disability. This condition is caused by the loss of one copy of the PMP22 gene or alterations within the gene.[1]

Last updated: 7/23/2009

References

  1. Hereditary neuropathy with liability to pressure palsies. Genetics Home Reference. April 2007; http://ghr.nlm.nih.gov/condition=hereditaryneuropathywithliabilitytopressurepalsies. Accessed 7/20/2009.
GARD Video Tutorials
GARD Video Tutorials
Learn how to find information on treatment, research, specialists, and more.
Your Questions Answered
Your Questions Answered
View questions about this condition answered by GARD Information Specialists. You can also submit a new question.

Basic Information

In Depth Information

  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Hereditary neuropathy with liability to pressure palsy. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Current pressure-sensitive neuropathy
  • Hereditary neuropathy with liability to pressure palsies
  • Heterozygous microdeletion 17p11.2p12
  • HNPP
  • Polyneuropathy, familial recurrent
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.