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Diseases

Genetic and Rare Diseases Information Center (GARD)

Hereditary neuropathy with liability to pressure palsy


Other Names for this Disease
  • Current pressure-sensitive neuropathy
  • Hereditary neuropathy with liability to pressure palsies
  • Heterozygous microdeletion 17p11.2p12
  • HNPP
  • Polyneuropathy, familial recurrent
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Treatment

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What treatments are available for hereditary neuropathy with liability to pressure palsy?

There is no specific treatment for hereditary neuropathy with liability to pressure palsy. Treatment is based on an individual's symptoms. Some people with this condition use braces, such as a wrist splint or ankle-foot orthosis (AFO). Protective pads worn at the elbows or knees may prevent pressure and trauma to local nerves. Activities to avoid include prolonged sitting with legs crossed, occupations requiring repetitive movements of the wrist, prolonged leaning on elbows, and rapid weight loss. Vincristine, commonly used in the treatment of lymphoma, has been reported to worsen the symptoms of hereditary neuropathy with liability to pressure palsy. Surgical decompression of nerves remains a controversial treament for this condition.[1]

Last updated: 7/24/2015

References
  1. Bird TD. Hereditary Neuropathy with Liability to Pressure Palsies. GeneReviews. September 25, 2014; http://www.ncbi.nlm.nih.gov/books/NBK1392/. Accessed 7/24/2015.


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Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions. Click on the link to view the article on this topic.

Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Hereditary neuropathy with liability to pressure palsy. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
  • Orphanet lists European clinical trials, research studies, and patient registries enrolling people with this condition. 
Other Names for this Disease
  • Current pressure-sensitive neuropathy
  • Hereditary neuropathy with liability to pressure palsies
  • Heterozygous microdeletion 17p11.2p12
  • HNPP
  • Polyneuropathy, familial recurrent
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.