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Diseases

Genetic and Rare Diseases Information Center (GARD)

Chromosome 15q duplication


Other Names for this Disease
  • 15q duplication
  • 15q trisomy
  • Duplication 15q
  • Partial trisomy 15q
  • Trisomy 15q
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Overview

Chromosome 15q duplication is a chromosome abnormality that occurs when an extra (duplicate) copy of the genetic material located on the long arm (q) of chromosome 15 is present in each cell. The severity of the condition and the associated signs and symptoms vary based on the size and location of the duplication and which genes are involved. Common features shared by many people with this duplication include developmental delay; intellectual disability; hypotonia (low muscle tone); seizures; high and/or cleft palate (roof of the mouth); scoliosis; slow growth; communication difficulties; behavioral problems; and distinctive facial features. Most cases are not inherited, although affected people can pass the duplication on to their children. Treatment is based on the signs and symptoms present in each person.[1][2][3]
Last updated: 4/6/2015

References

  1. 15q Duplications. Unique. 2014; http://www.rarechromo.org/information/Chromosome%2015/15q%20duplications%20FTNW.pdf.
  2. Understanding Dup15q. Dup15q Alliance. http://www.dup15q.org/understanding-dup15q/. Accessed 4/6/2015.
  3. Chromosome 15, Distal Trisomy 15q. NORD. 2009; http://rarediseases.org/rare-disease-information/rare-diseases/byID/1101/viewAbstract.
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Basic Information

  • Unique is a source of information and support to families and individuals affected by rare chromosome disorders. Click on the link to view information about duplications of 15q.

In Depth Information

  • PubMed is a searchable database of medical literature and lists journal articles that discuss Chromosome 15q duplication. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • 15q duplication
  • 15q trisomy
  • Duplication 15q
  • Partial trisomy 15q
  • Trisomy 15q
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.