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Diseases

Genetic and Rare Diseases Information Center (GARD)

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VLCAD deficiency


Other Names for this Disease
  • Very long-chain acyl-CoA dehydrogenase deficiency
  • VLCADD
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Prognosis

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What is the long-term outlook for people with VLCAD deficiency?

The long-term outlook (prognosis) for people with VLCAD deficiency is hard to predict and can vary based on the severity of the condition.

For people with the severe, early-onset form, cardiomyopathy and arrhythmias can be lethal. However, heart function can be improved with early treatment and specific diet modifications. Normal intellectual outcome has been reported in people with this form.[1]

For people with the hepatic (liver) or hypoketotic hypoglycemic form, hypoketotic hypoglycemia can cause a loss of consciousness or seizures.[1]

People with the later-onset episodic myopathic form may only have muscle-related symptoms. Some people with this form may not be diagnosed until adulthood. Since the later-onset form can have vague or intermittent symptoms, it is possible that some people may have no symptoms during their lifetime.[1]
Last updated: 6/29/2015

References
  1. Nancy D Leslie, MD, C Alexander Valencia, PhD, Arnold W Strauss, MD, Jessica Connor, MS, and Kejian Zhang, MD, MBA. Very Long-Chain Acyl-Coenzyme A Dehydrogenase Deficiency. GeneReviews. September 2014; http://www.ncbi.nlm.nih.gov/books/NBK6816/.


Other Names for this Disease
  • Very long-chain acyl-CoA dehydrogenase deficiency
  • VLCADD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.