Other Names for this Disease
- Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracic somite anomalies
- Klippel-feil deformity, conductive deafness, and absent vagina
fallopian tubes in females and the vas deferens in males), kidney abnormalities, and short stature (adult height of less than 5 feet).  Additional symptoms might include fused spinal bones in the neck and upper back and hearing loss. These symptoms may vary from person to person. MURCS association is present at birth but may not be noticed until after puberty, especially when an affected female does not receive her first period. This condition does not alter a person’s life expectancy.MURCS association stands for (MU)llerian, (R)enal, (C)ervicothoracic (S)omite abnormalities and is a developmental disorder that primarily affects the reproductive and urinary systems. Most individuals with MURCS association are female, although males can also have this condition. Females with MURCS association can have an absent or abnormally shaped uterus. In rare cases, the vagina is also affected. Both males and females with MURCS association can have absent or abnormally formed reproductive tubes (usually the
Last updated: 4/6/2011
- Duncan PA, Shapiro LR, Stangel JJ, Klein RM, Addonizio JC. The MURCS association: Mullerian duct aplasia, renal aplasia. J Pediatrics. 1979; 95(3):399. http://www.ncbi.nlm.nih.gov/pubmed/469663. Accessed 4/6/2011.
- Mahajan P, Kher A, Khungar A, Bhat M, Sanklecha M, Bharucha BA. MURCS association--a review of 7 cases. J Postgrad Med. 1992; 38:109. http://www.ncbi.nlm.nih.gov/pubmed/1303407. Accessed 4/6/2011.
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss MURCS association. Click on the link to view a sample search on this topic.