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Diseases

Genetic and Rare Diseases Information Center (GARD)

Acquired Von Willebrand syndrome


Other Names for this Disease
  • Willebrand disease, acquired
  • Acquired Von Willebrand disease
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Overview

Acquired von Willebrand syndrome (AVWS) is a bleeding disorder that can occur due to a variety of conditions, but is not caused by a VWF gene mutation. It is most often seen in persons over age 40 years with no prior bleeding history. This condition may result from lymphoproliferative disorders, autoimmune disorders (including systemic lupus erythrematosus, scleroderma, and antiphospholipid antibody syndrome), heart conditions such as aortic valvular stenosis, increased blood platelet count such as essential thrombocythemia, and certain drugs.[1] About 300 cases of this condition have been reported in the medical literature thus far. Treatment depends on the underlying cause of the condition.[2]
Last updated: 9/15/2011

References

  1. Goodeve A & James P. von Willebrand Disease. GeneReviews. October 2010; http://www.ncbi.nlm.nih.gov/books/NBK7014/#von-willebrand.Differential_Diagnosis. Accessed 9/15/2011.
  2. Acquired Von Willebrand syndrome. Orphanet. October 2008; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=99147. Accessed 9/15/2011.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Acquired Von Willebrand syndrome. This website is maintained by the National Library of Medicine.

In Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Acquired Von Willebrand syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Willebrand disease, acquired
  • Acquired Von Willebrand disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.