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Diseases

Genetic and Rare Diseases Information Center (GARD)

Prader-Willi syndrome


Other Names for this Disease
  • Prader-Labhart-Willi syndrome
  • PWS
  • Willi-Prader syndrome
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Inheritance

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Is Prader-Willi syndrome inherited?

Most cases of Prader-Willi syndrome (PWS) are not inherited. The genetic causes in these cases occur as random events during the formation of egg or sperm cells, or in early fetal development. In rare cases, the genetic change responsible for PWS can be inherited.[1]

The vast majority of families have a recurrence risk for PWS of less than 1%. However, certain causes of the condition have a recurrence risk as high as 50%, and a scenario with a risk of 100% (though extremely unlikely) is theoretically possible.[2]

The various genetic causes of PWS are very complex. People seeking detailed information about the genetics of PWS and the genetic risks to family members should speak with a genetics professional.
Last updated: 1/5/2015

References
  1. Prader-Willi syndrome. Genetics Home Reference. June, 2014; http://ghr.nlm.nih.gov/condition/prader-willi-syndrome. Accessed 1/5/2015.
  2. Driscoll DJ, Miller JL, Schwartz S, and Cassidy SB. Prader-Willi Syndrome. GeneReviews. January 23, 2014; http://www.ncbi.nlm.nih.gov/books/NBK1330/.


Other Names for this Disease
  • Prader-Labhart-Willi syndrome
  • PWS
  • Willi-Prader syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.