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Diseases

Genetic and Rare Diseases Information Center (GARD)

Prader-Willi syndrome


Other Names for this Disease
  • PWS
  • Willi-Prader syndrome
  • Prader-Labhart-Willi syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Inheritance

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Is Prader-Willi syndrome inherited?

Most cases of Prader-Willi syndrome (PWS) are not inherited and are due to random events during the formation of egg or sperm cells, or in early fetal development. This is usually the case when PWS is caused by a deletion in the paternal chromosome 15, or by maternal uniparental disomy. However in rare cases, a genetic change responsible for PWS can be inherited.[1]

The risk to family members of a person with PWS depends on the genetic cause of the condition in the affected person.[2] Because the various genetic causes of PWS are complex, people seeking information about specific risks to themselves or family members are encouraged to speak with a genetics professional.

More information about the causes of PWS can be viewed on our website here.
Last updated: 7/7/2016

References
  1. Prader-Willi syndrome. Genetics Home Reference. June 2014; https://ghr.nlm.nih.gov/condition/prader-willi-syndrome#.
  2. Driscoll DJ, Miller JL, Schwartz S, and Cassidy SB. Prader-Willi Syndrome. GeneReviews. February 4 2016; http://www.ncbi.nlm.nih.gov/books/NBK1330/.


Other Names for this Disease
  • PWS
  • Willi-Prader syndrome
  • Prader-Labhart-Willi syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.