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Diseases

Genetic and Rare Diseases Information Center (GARD)

47, XYY syndrome


Other Names for this Disease
  • YY syndrome
  • XYY syndrome
  • XYY Karyotype
  • Jacobs syndrome
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Overview

47, XYY syndrome is a condition in males characterized by features that occur due to having an extra copy of the Y chromosome in each cell. Signs and symptoms can vary and range from barely noticeable to more severe; many men with the extra Y chromosome are completely unaware of its presence.[1] Appearance and intelligence are usually normal, but learning disabilities may be present. Other signs and symptoms may include autism spectrum disorder (usually on the milder end); speech or motor delay; low muscle tone; asthma; tall stature; impaired social skills; ADHD; and/or anxiety or mood disorders.[1][2] While sexual development and infertility is usually normal, some adolescents and adults have testicular failure.[1] 47, XYY syndrome usually is not inherited, occurring due to a random event in the formation of a sperm cell prior to conception.[3] Management depends on the symptoms in each person and may include intervention or therapies for developmental delays, behavior or mood disorders; and/or special education.[1]
Last updated: 4/12/2016

References

  1. Frequently Asked Questions Related to 47, XYY. Klinefelter Syndrome and Associates (KS&A). 2013; http://www.genetic.org/Portals/0/Public/Docs/XYY%20FAQ%20-%20FINAL%20-%20Rev%208-2-12.pdf.
  2. XYY. Unique. 2014; http://www.rarechromo.org/information/Chromosome_Y/XYY%20FTNW.pdf.
  3. 47,XYY syndrome. Genetics Home Reference. January 2009; http://ghr.nlm.nih.gov/condition/47xyy-syndrome. Accessed 4/29/2011.
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Basic Information

In Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss 47, XYY syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • YY syndrome
  • XYY syndrome
  • XYY Karyotype
  • Jacobs syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.