Other Names for this Disease
- Autism, dementia, ataxia, and loss of purposeful hand use
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Although Rett syndrome is a genetic disorder, less than 1 percent of recorded cases are inherited or passed from one generation to the next. Most cases are sporadic, which means the mutation occurs randomly, and are not inherited. A few families have been described with more than one affected family member. These cases helped researchers determine that Rett syndrome has an X-linked dominant pattern of inheritance. A condition is considered X-linked if the mutated gene that causes the disorder is located on the X chromosome, one of the two sex chromosomes. The inheritance is dominant if one copy of the altered gene in each cell is sufficient to cause the condition.
Last updated: 4/25/2016
- Rett syndrome. Genetics Home Reference (GHR). December 2013; https://ghr.nlm.nih.gov/condition/rett-syndrome.