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Diseases

Genetic and Rare Diseases Information Center (GARD)

Adiposis dolorosa


Other Names for this Disease
  • Dercum disease
  • Dercum's disease
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Treatment

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How might adiposis dolorosa be treated?

Management of adiposis dolorosa is difficult and no currently available treatments have led to long-lasting, complete pain reduction.[1] Surgical removal of particularly burdensome lesions and/or liposuction may be helpful for some people. However, lipomas have been known to reoccur and even increase in number at the same site or a nearby location.[2] Weight reduction may help with joint pain in some individuals, but has proven to be difficult to achieve and generally doesn't offer significant relief of symptoms.[2] There is currently no drug known to change the course of the disease. Available treatments mainly focus on alleviating symptoms and may include:[3]
  • prednisone or intravenous lidocaine for pain
  • traditional pain medicines such nonsteroidal anti-inflammatory drugs (which are often ineffective), or acetaminophen combined with an opioid analgesic
  • a cortisone/anesthetic injection for localized pain
  • diuretics for swelling of the fingers
Other treatments that have led to some pain reduction in some affected people include methotrexate and infliximab; interferon α-2b; calcium-channel modulators; and rapid cycling hypobaric pressure.[1] Adjunctive therapies may include acupuncture, cognitive behavioral therapy, hypnosis, and biofeedback.[3]
Last updated: 6/28/2016

References
  1. Hansson E, Svensson H, Brorson H. Review of Dercum's disease and proposal of diagnostic criteria, diagnostic methods, classification and management.. Orphanet Journal of Rare Diseases. 2012; 7:23. http://ojrd.biomedcentral.com/articles/10.1186/1750-1172-7-23.
  2. Dercum's Disease (DD). Fat Disorders Research Society. http://www.fatdisorders.org/fat-disorders/dercums-description.
  3. Laura F McGevna. Adiposis Dolorosa. Medscape Reference. February 6, 2015; http://emedicine.medscape.com/article/1082083-treatment.


Clinical Trials & Research for this Disease

  • The Centers for Mendelian Genomics program is working to discover the causes of rare genetic disorders. For more information about applying to the research study, please visit their website.
Other Names for this Disease
  • Dercum disease
  • Dercum's disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.