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Diseases

Genetic and Rare Diseases Information Center (GARD)

Adiposis dolorosa


Other Names for this Disease
  • Dercum disease
  • Dercum's disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Cause

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What causes adiposis dolorosa?

The exact cause of adiposis dolorosa remains unknown. While possible causes have been suggested, none have been confirmed. These include long-term treatment with high-dose corticosteroids; endocrine system abnormalities; nervous system dysfunction; mechanical pressure on nerves, adipose tissue dysfunction; trauma; and changes in fatty acid or carbohydrate metabolism. Researchers have also suggested that it could be an autoimmune disorder.[1][2][3][4]

Because the condition has rarely occurred in more than one person within a family, it may have a genetic component. However, no specific gene known to be associated with the condition has been identified.[2][3][4]

Last updated: 2/4/2016

References
  1. Learning About Dercum Disease. NHGRI. June 27, 2012; http://www.genome.gov/17516629.
  2. Hansson E, Svensson H, Brorson H. Review of Dercum's disease and proposal of diagnostic criteria, diagnostic methods, classification and management.. Orphanet Journal of Rare Diseases. 2012; 7:23. http://ojrd.biomedcentral.com/articles/10.1186/1750-1172-7-23.
  3. Adiposis dolorosa. Genetics Home Reference. July, 2012; http://ghr.nlm.nih.gov/condition/adiposis-dolorosa.
  4. Dercum's Disease (DD). Fat Disorders Research Society. http://www.fatdisorders.org/fat-disorders/dercums-description.


Other Names for this Disease
  • Dercum disease
  • Dercum's disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.