Amyotrophic lateral sclerosis
Other Names for this Disease
- Lou Gehrig disease
- Amyotrophic lateral sclerosis type 1
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motor neuron disease which leads to problems with muscle control and movement. There are various types of ALS, which are distinguished by their signs and symptoms and their cause. Early symptoms may include muscle twitching, cramping, stiffness, or weakness, eventually followed by slurred speech and difficulty chewing or swallowing (dysphagia). As the disease progresses, individuals become weaker are are eventually wheelchair-dependent. Death often results from respiratory failure within 2 to 10 years after the onset of symptoms. Most affected individuals have a sporadic (not inherited) form of ALS; about 5-10% have a familial (inherited) form of the condition. Familial ALS may caused by mutations in any one of several genes and the pattern of inheritance varies depending on the gene involved. Treatment is generally supportive.Amyotrophic lateral sclerosis (ALS), also referred to as "Lou Gehrig's disease," is a progressive
Last updated: 1/7/2013
- Donkervoort S, Siddique T. Amyotrophic Lateral Sclerosis. GeneReviews . 2009; http://www.ncbi.nlm.nih.gov/books/NBK1450/. Accessed 4/12/2011.
- Amyotrophic lateral sclerosis. Genetics Home Reference. August 2012; http://ghr.nlm.nih.gov/condition/amyotrophic-lateral-sclerosis. Accessed 1/7/2013.
- Nigel Leigh and Lokesh Wijesekera. Amyotrophic lateral sclerosis. Orphanet. May 2011; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=803. Accessed 1/7/2012.
- Genetics Home Reference (GHR) contains information on Amyotrophic lateral sclerosis. This website is maintained by the National Library of Medicine.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Online Mendelian Inheritance in Man (OMIM) lists the subtypes and associated genes for Amyotrophic lateral sclerosis in a table called Phenotypic Series. Each entry in OMIM includes a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Amyotrophic lateral sclerosis. Click on the link to view a sample search on this topic.