enamel of the teeth. This condition causes teeth to be unusually small, discolored, pitted or grooved, and prone to rapid wear and breakage. These dental problems, which vary among affected individuals, can affect both primary (baby) teeth and permanent teeth. There are 4 main types of AI that are classified based on the type of enamel defect. These 4 types are divided further into 14 subtypes, which are distinguished by their specific dental abnormalities and by their pattern of inheritance. AI can be inherited in an autosomal dominant, autosomal recessive or X-linked recessive pattern.Amelogenesis imperfecta (AI) (amelogenesis - enamel formation; imperfecta - imperfect) is a disorder that affects the structure and appearance of the
Last updated: 12/12/2013
- Wright JT. Amelogenesis Imperfecta. Developmental Defects of the Teeth. https://www.dentistry.unc.edu/dentalprofessionals/resources/defects/ai/. Accessed 9/17/2015.
- Amelogenesis imperfecta. Genetics Home Reference (GHR). May 2015; http://ghr.nlm.nih.gov/condition/amelogenesis-imperfecta. Accessed 9/10/2015.
- Genetics Home Reference (GHR) contains information on Amelogenesis imperfecta. This website is maintained by the National Library of Medicine.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
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