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Genetic and Rare Diseases Information Center (GARD)

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AL amyloidosis


Other Names for this Disease
  • Amyloidosis AL
  • Amyloidosis primary systemic
  • Light chain amyloidosis
  • Localized AL amyloidosis
  • Localized immunoglobulinic amyloidosis
Related Diseases
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Overview

AL amyloidosisis the most common form of amyloidosis, a group of disorders in which an abnormal protein called amyloid builds up in tissues and organs. The signs and symptoms of AL amyloidosis vary among patients because the build up may occur in the tongue, intestines, muscles, joints, nerves, skin, ligaments, heart, liver, spleen, or kidneys. To diagnose AL amyloidosis, healthcare professionals use blood or urine tests to identify signs of amyloid protein and a biopsy to confirm the diagnosis. Treatment may include chemotherapy directed at the abnormal plasma cells, stem cell transplantation, or other treatments based on which symptoms have developed.[1]
[2]
Last updated: 7/17/2015

References

  1. AL Amyloidosis. Amyloidosis Foundation. June 30, 2015; http://www.amyloidosis.org/facts/al/. Accessed 7/17/2015.
  2. Dugdale DC. Primary amyloidosis. MedlinePlus. January 1, 2013; http://www.nlm.nih.gov/medlineplus/ency/article/000533.htm.
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Basic Information

  • The Mayo Clinic provides information on the diagnosis and treatment of amyloidosis.
  • Amyloidosis Awareness is an illustrated booklet for patients and physicians developed by Amyloidosis Support Groups Inc. Versions of the booklet are also available in Spanish and Portuguese.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC), part of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), conducts and supports research on a broad spectrum of diseases affecting public health. Click on the link to view information on this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
    Immunoglobulin-Related Amyloidosis
    Primary Systemic Amyloidosis
  • PubMed is a searchable database of medical literature and lists journal articles that discuss AL amyloidosis. Click on the link to view a sample search on this topic.

Selected Full-Text Journal Articles

  • The Orphanet Journal of Rare Diseases has published an article with information on this condition. This journal is affiliated with the Orphanet reference portal for information on rare diseases and orphan drugs.
Other Names for this Disease
  • Amyloidosis AL
  • Amyloidosis primary systemic
  • Light chain amyloidosis
  • Localized AL amyloidosis
  • Localized immunoglobulinic amyloidosis
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.