- Familial antiphospholipid syndrome
- Antiphospholipid antibody syndrome
- Lupus anticoagulant, familial
- Hughes syndrome
Your QuestionCan you provide me with the latest figures for patients with antiphospholipid syndrome in the United States and in the United Kingdom, as well as the percentage of the world population affected by this condition?
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There are no definitive facts about the number of people with antiphospholipid (aPL) antibodies or antiphospholipid syndrome (APS) in the United States (US). What we know is based on estimates from different studies over time. Research suggests that aPL antibodies may be found in about 1 to 5 percent of the healthy general population. The number of affected individuals increases with age.
About 50% of people with APS have primary APS, which is when their APS is not associated with another disease. Secondary APS is when the APS occurs with systemic lupus erythematosus (SLE) or another autoimmune disorder. Studies show that between 5-30 percent of individuals with blood clots, and no history of SLE, have aPL antibodies. In people with SLE, approximately 30 percent have aPL antibodies, and around 30-50 percent of these individuals have symptoms and signs of APS. Additional studies suggest that aPL antibodies may play a role in about one-third of strokes in people under the age of 50.
- Learning About Antiphospholipid Syndrome (APS). National Institute of Human Genome Research (NHGRI). February 25, 2009; http://www.genome.gov/17516396. Accessed 2/25/2009.
- Belilos E, Carsons S. Antiphospholipid Syndrome. eMedicine. August 10, 2007; http://emedicine.medscape.com/article/333221-overview. Accessed 2/25/2009.
- Tektonidou M. Orphanet Encyclopedia. July 2011; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=80.
- Antiphospholipid Antibody Syndrome: The Statistics. APS Foundation of America. October 2006; http://www.apsfa.org/aps.htm#4. Accessed 2/25/2009.