Aplasia cutis congenita
- Aplasia cutis congenita nonsyndromic
- Congenital defect of skull and scalp
- Scalp defect congenital
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Local therapy includes gentle cleansing and the application of bland ointment or silver sulfadiazine ointment to keep the area moist. Antibiotics may be utilized if overt signs of infection are noted. In many cases, other treatment is not necessary because the erosions and the ulcerations almost always heal on their own. Recently, a variety of specialized dressing materials have been developed and used.
Surgical repair is not usually indicated if the defect is small. Recovery is generally uneventful, with gradual epithelialization and formation of a hairless, atrophic scar over several weeks. Small underlying bony defects usually close spontaneously during the first year of life. Surgical repair of large or multiple scalp defects may require excision with primary closure, if feasible, or the use of tissue expanders and rotation of a flap to fill the defect. On occasion, skin and bone grafts may also be required.
- Santos de Oliveira R, Barros Juca CE, Lopes Lins-Neto A, Aparecida do Carmo Rego M, Farina J, Machado HR. Childs Nerv Syst. 2006; http://www.ncbi.nlm.nih.gov/pubmed/16639628. Accessed 1/19/2010.
- Basterzi Y, Bagdatoglu C, Sari A, Demirkan F. J Craniofac Surg. 2007; http://www.ncbi.nlm.nih.gov/pubmed/17414296. Accessed 1/19/2010.
- Crowe MA. Aplasia Cutis Congenita: Treatment & Medication. eMedicine. 2010; http://emedicine.medscape.com/article/1110134-treatment. Accessed 1/19/2010.
- Finding Treatment Information - A video developed by GARD Information Specialists that explains how you can find information about treatment for a rare disease.
- The Centers for Mendelian Genomics program is working to discover the causes of rare genetic disorders. For more information about applying to the research study, please visit their website.