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Genetic and Rare Diseases Information Center (GARD)


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How might aspergillosis be treated?

If the infection is widespread or the person appears seriously ill, treatment is started immediately.[1] Voriconazole is currently first-line treatment for invasive aspergillosis and is usually given intravenously.[2][3] There are other antifungal drugs that can be used to treat invasive aspergillosis in patients who cannot take voriconazole or who have not responded to voriconazole. These include itraconazole, lipid amphotericin formulations, caspofungin, micafungin, and posaconazole. Whenever possible, immunosuppressive medications should be discontinued or decreased.[2][1]

A fungus ball usually does not require treatment unless bleeding into the lung tissue is associated with the infection, then surgery is required. Antifungal agents do not help people with allergic aspergillosis. Allergic aspergillosis is treated with prednisone taken by mouth.[3]
Last updated: 10/2/2013

  1. Aspergillosis. Merck Manuals Online Medical Library. October 2008; Accessed 10/2/2013.
  2. Aspergillosis (Aspergillus). Centers for Disease Control and Prevention (CDC). May 6, 2013; Accessed 10/2/2013.
  3. Aspergillosis. MedlinePlus. June 9, 2011; Accessed 10/2/2013.

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Clinical Trials & Research for this Disease

  • lists trials that are studying or have studied Aspergillosis. Click on the link to go to to read descriptions of these studies.

Medical Products

The medication(s) listed in the table(s) below have been approved by the Food and Drug Administration (FDA) for treatment of this condition. The FDA Office of Orphan Products Development designates "orphan products" for those that treat rare diseases affecting fewer than 200,000 Americans. The table(s) below may not be an exhaustive list of drugs or products used to treat this condition. There may be other products available that are not considered orphan products. To search for all FDA approved drugs, visit Drugs@FDA. You can find orphan products used to treat other conditions by searching the Orphan Drug Product Designation database.

Generic Name isavuconazonium sulfate
Trade Name
(Manufacturer Name)
The FDA has approved this product to be used in this manner.
Treatment of invasive aspergillosis in patients 18 years of age and older.
More Information about this product Drug Information Portal

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