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Diseases

Genetic and Rare Diseases Information Center (GARD)

Tumefactive multiple sclerosis


Other Names for this Disease
  • Diffuse cerebral sclerosis of Schilder
  • Concentric demyelination
  • Balo's concentric sclerosis
  • Marburg variant
  • Balo disease
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Tumefactive multiple sclerosis is characterized by a tumor-like lesion larger than two centimeters and signs and symptoms similar to those of a brain tumor.[1][2] It is a rare form of multiple sclerosis (MS). Symptoms of tumefactive MS often differ from other MS cases and may include, headaches, changes in thinking, confusion, speech problems, seizures, and weakness.[1] The cause of tumefactive MS is not known. It often develops into the relapsing-remitting form of MS.[2][3] In other cases there is only one occurrence of the condition.[2] In still others the disease process remains less clear. While there is no cure for tumefactive MS, treatments such as corticosteroids are available to decrease disease activity.[2][3]
Last updated: 5/18/2016

References

  1. Tumefactive Multiple Sclerosis. Cedars-Sinai. 2016; https://www.cedars-sinai.edu/Patients/Health-Conditions/Tumefactive-Multiple-Sclerosis.aspx. Accessed 5/18/2016.
  2. Olek MJ. Diagnosis of multiple sclerosis in adults. In: Gonzalez-Scarano F. ed. UpToDate. Waltham, MA: UpToDate; February 22, 2016; Accessed 5/18/2016.
  3. Hardy TA, Chataway J. Tumefactive demyelination: an approach to diagnosis and management. Neurol Neurosurg Psychiatry. 2013; 84:1047. Accessed 5/18/2016.
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Basic Information

  • The National MS Society offers an overview on tumefactive multiple sclerosis, including information on symptoms and treatment.
  • The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.

In Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Tumefactive multiple sclerosis. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Diffuse cerebral sclerosis of Schilder
  • Concentric demyelination
  • Balo's concentric sclerosis
  • Marburg variant
  • Balo disease
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.