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Diseases

Genetic and Rare Diseases Information Center (GARD)

Tumefactive multiple sclerosis


Other Names for this Disease
  • Diffuse cerebral sclerosis of Schilder
  • Balo's concentric sclerosis
  • Marburg variant
  • Balo disease
  • Baló concentric sclerosis
Related Diseases
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Treatment

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How is tumefactive multiple sclerosis treated?

To date there have been no controlled treatment studies for tumefactive multiple sclerosis. As a result, treatment decisions are largely based on a doctor's experience and information from single case reports.[1]

In a small number of cases, people with tumefactive multiple sclerosis have minimal to no symptoms. A reasonable approach of care in these cases is to monitor without treatment.[1]

In most cases the size of the lesion and resulting symptoms prompts treatment with corticosteroids. As with other forms of multiple sclerosis, corticosteroids (for example, intravenous methylprednisolone) should be the first line of treatment.  If corticosteroids are not effective, plasma exchange is tried. Another second line treatment that has been tried with some success is Rituximab.[1]
Last updated: 5/19/2016

References
  1. Hardy TA, Chataway J. Tumefactive demyelination: an approach to diagnosis and management. Neurol Neurosurg Psychiatry. 2013; 84:1047. Accessed 5/18/2016.


GARD Video Tutorial

  • Finding Treatment Information - A video developed by GARD Information Specialists that explains how you can find information about treatment for a rare disease.

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Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Tumefactive multiple sclerosis. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • Diffuse cerebral sclerosis of Schilder
  • Balo's concentric sclerosis
  • Marburg variant
  • Balo disease
  • Baló concentric sclerosis
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.