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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Budd-Chiari syndrome


Other Names for this Disease
  • Hepatic vein obstruction
  • Hepatic veno-occlusive disease
  • Rare dementia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Budd-Chiari syndrome is a rare disorder characterized by narrowing and obstruction of the veins of the liver.[1] This narrowing or obstruction slows or prevents blood from flowing out of the liver and back to the heart which can lead to liver damage.[2] While some people experience no symptoms, many experience fatigue, abdominal pain, nausea, and jaundice. Other associated findings include an accumulation of fluid in the abdomen (ascites), an enlarged spleen and/or liver, and severe bleeding in the esophagus.[1][3] The severity of the disorder varies from case to case, depending on the site and number of affected veins.[1] Drugs may be used to dissolve or decrease the size of the obstruction (if it is a clot). In some cases surgery is performed.[3] In most cases, the cause of Budd-Chiari syndrome is unknown.[1]
Last updated: 10/30/2010

References

  1. Budd Chiari Syndrome. National Organization for Rare Disorders (NORD). 2007; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Budd%20Chiari%20Syndrome. Accessed 10/30/2010.
  2. Dugdale DC, Longstreth GF. Hepatic vein obstruction (Budd-Chiari). MedlinePlus. 2010; http://www.nlm.nih.gov/medlineplus/ency/article/000239.htm. Accessed 10/30/2010.
  3. Shaffer EA. Budd-Chiari Syndrome. Merck Online Medical Library . 2007; http://www.merck.com/mmhe/sec10/ch138/ch138d.html. Accessed 10/30/2010.
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Basic Information

  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers. 
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • MeSH® (Medical Subject Headings) is a terminology tool used by the National Library of Medicine. Click on the link to view information on this topic.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Budd-Chiari syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Hepatic vein obstruction
  • Hepatic veno-occlusive disease
  • Rare dementia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.