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Diseases

Genetic and Rare Diseases Information Center (GARD)

Canavan disease


Other Names for this Disease
  • ACY2 deficiency
  • Aminoacylase 2 deficiency
  • ASP deficiency
  • ASPA deficiency
  • Aspartoacylase deficiency
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

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How might Canavan disease be treated?

Canavan disease causes progressive brain atrophy. There is no cure, nor is there a standard course of treatment. Treatment is symptomatic and supportive.[1][2] 

Management may include provision of adequate nutrition and hydration, treatment of infectious diseases, and protection of the airway. Physical therapy may help to minimize contractures and maximize motor abilities and seating posture. Special education programs can enhance communication skills. Seizures are treated with anti-epileptic drugs. Gastrostomy can help to maintain adequate food intake and hydration when swallowing difficulties exist.[3]
Last updated: 5/15/2015

References
  1. NINDS Canavan Disease Information Page. National Institute of Neurological Disorders and Stroke (NINDS). June 13, 2013; http://www.ninds.nih.gov/disorders/canavan/canavan.htm. Accessed 5/14/2015.
  2. Haldeman- Englert C. Canavan disease. MedlinePlus. October 29, 2013; http://www.nlm.nih.gov/medlineplus/ency/article/001586.htm. Accessed 5/14/2015.
  3. Matalon R, Michals-Matalon K. Canavan Disease. GeneReviews. August 11, 2011; http://www.ncbi.nlm.nih.gov/books/NBK1234/. Accessed 5/15/2015.


GARD Video Tutorial

  • Finding Treatment Information - A video developed by GARD Information Specialists that explains how you can find information about treatment for a rare disease.

    Finding Treatment Information

Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions. Click on the link to view the article on this topic.

Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Canavan disease. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
  • Orphanet lists European clinical trials, research studies, and patient registries enrolling people with this condition. 
Other Names for this Disease
  • ACY2 deficiency
  • Aminoacylase 2 deficiency
  • ASP deficiency
  • ASPA deficiency
  • Aspartoacylase deficiency
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.